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Hiroki Okada Selected Research

ONO-8055

1/2020Further characterization of a novel EP2 and EP3 receptor dual agonist, ONO-8055, on lower urinary tract function in normal and lumbar canal stenosis rats.
5/2018Effects of an EP2 and EP3 Receptor Dual Agonist, ONO-8055, on a Radical Hysterectomy-Induced Underactive Bladder Model in Monkeys.
8/2016Promising Effects of a Novel EP2 and EP3 Receptor Dual Agonist, ONO-8055, on Neurogenic Underactive Bladder in a Rat Lumbar Canal Stenosis Model.

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Hiroki Okada Research Topics

Disease

6Esophageal Achalasia (Megaesophagus)
12/2023 - 01/2019
5Underactive Urinary Bladder
01/2020 - 11/2014
3Pain (Aches)
10/2022 - 06/2011
3Neoplasms (Cancer)
04/2022 - 07/2016
3Pathologic Constriction (Stenosis)
01/2020 - 11/2014
3Hypertension (High Blood Pressure)
07/2015 - 01/2012
2Esophageal Motility Disorders (Nutcracker Esophagus)
12/2023 - 10/2022
2Pancreatic Neoplasms (Pancreatic Cancer)
05/2023 - 01/2021
2Heartburn (Pyrosis)
07/2015 - 03/2013
2Interstitial Cystitis (Interstitial Cystitis, Chronic)
06/2015 - 06/2011
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
04/2024
1Fistula
04/2024
1Body Weight (Weight, Body)
01/2024
1Parkinson Disease (Parkinson's Disease)
01/2024
1Gastroesophageal Reflux (GERD)
10/2023
1Hemorrhage
02/2023
1Missed Abortion
02/2023
1Spontaneous Abortion (Miscarriage)
02/2023
1Chest Pain (Chest Pains)
10/2022
1Portal Hypertension
02/2022
1Dyspepsia (Indigestion)
01/2022
1Psoriasis (Pustulosis Palmaris et Plantaris)
03/2021
1Myopia 2
04/2019
1Mediastinitis
01/2019
1Candidiasis (Moniliasis)
09/2018
1Fibrosis (Cirrhosis)
08/2017
1Spinal Cord Injuries (Spinal Cord Injury)
08/2017
1Ischemia
08/2017
1Mycoses (Diseases, Fungus)
08/2015
1Postoperative Pain
07/2015
1Diabetes Mellitus
07/2015
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2014
1Atherosclerosis
04/2013
1Hypersensitivity (Allergy)
03/2013
1Heart Diseases (Heart Disease)
01/2013
1Arteriosclerosis
01/2012
1Heart Failure
01/2012
1Cystitis
06/2011
1Hyperalgesia
06/2011
1Esophageal and Gastric Varices (Esophageal Varices)
05/2010

Drug/Important Bio-Agent (IBA)

5Dinoprostone (PGE2)FDA Link
01/2022 - 06/2011
3ONO-8055IBA
01/2020 - 08/2016
3Messenger RNA (mRNA)IBA
01/2020 - 06/2015
3ProstaglandinsIBA
05/2018 - 06/2011
2Tadalafil (Cialis)FDA Link
01/2020 - 08/2017
2Phosphodiesterase 5 InhibitorsIBA
01/2020 - 08/2017
2Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
01/2020 - 08/2017
2Adrenergic Receptors (Adrenergic Receptor)IBA
08/2017 - 11/2014
2AcidsIBA
07/2015 - 03/2013
28-Hydroxy-2'-DeoxyguanosineIBA
01/2013 - 01/2012
1Phenobarbital (Luminal)FDA Link
04/2024
1Serum AlbuminIBA
01/2024
1Adenosine (Adenocard)FDA LinkGeneric
01/2024
1Proton Pump InhibitorsIBA
10/2023
1brodalumabIBA
03/2021
1PlatinumIBA
01/2021
1Therapeutic UsesIBA
01/2020
1salicylhydroxamic acid (SHAM)IBA
01/2020
1Myosin Type IIIBA
04/2019
1Protein Isoforms (Isoforms)IBA
04/2019
1Caspofungin (Cancidas)FDA Link
09/2018
1CollagenIBA
08/2017
1naftopidilIBA
08/2017
1ElastinIBA
08/2017
1Antifungal AgentsIBA
08/2015
1Dental Implants (Dental Implant)IBA
07/2015
1Analgesics (Analgesic Drugs)IBA
07/2015
1Diclofenac (SR 38)FDA LinkGeneric
07/2015
1Prostaglandin Receptors (Prostaglandin Receptor)IBA
06/2015
1Cholinesterase Inhibitors (Anticholinesterases)IBA
11/2014
1Antihypertensive Agents (Antihypertensives)IBA
01/2014
1Prostaglandins EIBA
03/2013
1Peptides (Polypeptides)IBA
01/2012
1Brain Natriuretic Peptide (Natrecor)FDA Link
01/2012
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2011
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2011
1ethanolamine oleate (Ethamolin)FDA Link
05/2010

Therapy/Procedure

6Myotomy
12/2023 - 01/2019
2Therapeutics
10/2023 - 01/2014
2Radiotherapy
05/2023 - 01/2021
2Catheters
02/2023 - 05/2010
2Hysterectomy
02/2023 - 05/2018
2Nerve Crush
01/2020 - 11/2018
1Ligation
04/2024
1Oral Administration
01/2024
1Conservative Treatment
02/2023
1Uterine Artery Embolization
02/2023
1Curettage
02/2023
1Endoscopes
04/2022
1Surgical Portasystemic Shunt (Portosystemic Shunt)
02/2022
1General Anesthesia
07/2016
1Local Anesthesia
07/2015
1Premedication
07/2015
1Anesthesia
06/2015
1Drug Therapy (Chemotherapy)
11/2014
1Ambulatory Care (Outpatient Care)
04/2013